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PUROMYCIN AMINONUCLEOSIDE

Product Name
PUROMYCIN AMINONUCLEOSIDE
CAS No.
58-60-6
Chemical Name
PUROMYCIN AMINONUCLEOSIDE
Synonyms
ARDMA;Nsc3056;Aids000507;Aids-000507;aminonucleoside;3′-Amino-3′-deoxy-N6;aminonucleosidepuromycin;PuroMycin aMinonucleosid;PUROMYCIN AMINONUCLEOSIDE;stylomycinaminonucleoside
CBNumber
CB5455647
Molecular Formula
C12H18N6O3
Formula Weight
294.31
MOL File
58-60-6.mol
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PUROMYCIN AMINONUCLEOSIDE Property

Melting point:
235℃ (Decomposition)
Boiling point:
436.08°C (rough estimate)
Density 
1.2131 (rough estimate)
refractive index 
1.7000 (estimate)
Flash point:
>110°(230°F)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: 50 mg/mL, clear, slightly yellow
form 
liquid
pka
13.26±0.70(Predicted)
color 
White
Water Solubility 
Soluble in water at 50mg/ml. May require heating
BRN 
93902
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
InChIKey
RYSMHWILUNYBFW-GRIPGOBMSA-N
EPA Substance Registry System
Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl- (58-60-6)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
48/22
WGK Germany 
3
RTECS 
AU7337000
F 
10-21
TSCA 
Yes
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P7130
Product name
Puromycin aminonucleoside
Packaging
100mg
Price
$528.8
Updated
2024/03/01
Sigma-Aldrich
Product number
P7130
Product name
Puromycin aminonucleoside
Packaging
1g
Price
$3920
Updated
2024/03/01
Alfa Aesar
Product number
J66301
Product name
Puromycin aminonucleoside, 98%
Packaging
100mg
Price
$561
Updated
2024/03/01
Alfa Aesar
Product number
J66301
Product name
Puromycin aminonucleoside, 98%
Packaging
500mg
Price
$2040
Updated
2024/03/01
Cayman Chemical
Product number
15509
Product name
Puromycin Aminonucleoside
Purity
≥98%
Packaging
10mg
Price
$62
Updated
2024/03/01
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PUROMYCIN AMINONUCLEOSIDE Chemical Properties,Usage,Production

Description

Puromycin aminonucleoside (58-60-6) is the nucleoside moiety of puromycin (Cat.# 10-2100) which does not inhibit protein synthesis or induce apoptosis.1?It acts as a glomerular epithelial cell toxin2 and as such is a useful tool for producing animal models of nephropathy3,4, or puromycin aminonucleoside nephrosis (1-2.5 mg/100g rat body weight)5. Active in vivo.

Chemical Properties

White crystal

Uses

Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumour properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells.

Uses

Puromycin Aminonucleoside is an aminonucleoside portion of the antibiotic puromycin.

Definition

ChEBI: Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring.

Safety Profile

An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.

References

1) Chow et al. (1995), Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis; Exp. Cell Res., 216 149 2) Krishnamurti et al. (2001), Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells; J. Am. Soc. Nephrol., 12 758 3) Egashira et al. (2006), Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis; Int. J. Vitam. Nutr. Res., 76 28 4) Hagiwara et al. (2006), Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis; Kidney Int., 69 1146 5) Lowenborg et al. (2000), Glomerular function and morphology in puromycin aminonucleoside nephropathy in rats; Nephrol. Dial. Transplant, 15 1547

PUROMYCIN AMINONUCLEOSIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PUROMYCIN AMINONUCLEOSIDE Suppliers

China 144 China Hong Kong 1 Germany 3 Japan 1 Switzerland 2 United Kingdom 4 United States 18 Global 173
TopScience Biochemical
Tel
00852-68527855
Fax
00852-26406298
Email
info@itopbiochem.com
Country
China Hong Kong
ProdList
902
Advantage
58
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View Lastest Price from PUROMYCIN AMINONUCLEOSIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Puromycin aminonucleoside 58-60-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-09
Dideu Industries Group Limited
Product
PUROMYCIN AMINONUCLEOSIDE 58-60-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-24
Career Henan Chemical Co
Product
PUROMYCINAMINONUCLEOSIDE 58-60-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
KG/T
Release date
2019-12-17

58-60-6, PUROMYCIN AMINONUCLEOSIDERelated Search:

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  • 3’-amino-3’-deoxy-n,n-dimethyl-adenosin
  • 6-(dimethylamino)-9-(3-amino-3-deoxy-beta-d-ribofuranosyl)purine
  • 9-(3-amino-3-deoxy-beta-d-ribofuranosyl)-6-(dimethylamino)-9h-purine
  • aminonucleoside
  • aminonucleosidepuromycin
  • stylomycinaminonucleoside
  • PUROMYCIN AMINONUCLEOSIDE
  • 6-DIMETHYLAMIN-9-[3'-AMINO-3'DEOXYRIBOSYL]-PURINE
  • Puromycin Aminonucleoside, 6-Dimethylamin-9-[3-amino-3deoxyribosyl]-purine
  • 9-(3-Amino-3-deoxy-.beta.-D-ribofuranosyl)-N,N-dimethyl-9H-purin-6-amine
  • Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl-
  • Aids000507
  • Aids-000507
  • Nsc3056
  • PuroMycin aMinonucleosid
  • 3'-DiMethylaMino-3'-deoxyadenosine
  • 3'-AMINO-3'-DEOXY-N6,N6-DIMETHYLADENOSINE
  • 3'-AMINO-3'-DEOXY-N,N-DIMETHYL-ADENOSINE
  • SAN Puromycin-Amino-Nucleoside NSC 3056 Aminonucleoside puromycin PANS
  • (2R,3R,4S,5S)-4-amino-2-(6-(dimethylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol
  • Puromycin aminonucleoside Ready Made Solution
  • puromycin aminonucleoside (PAN)
  • 3′-Amino-3′-deoxy-N6
  • 3’-Amino-3’-deoxy-N6,N6-dimethyladenosine, puromycin aminonucleoside (PAN)
  • PUROMYCIN AMINONUCLEOSIDE USP/EP/BP
  • (2R,3R,4S,5S)-4-amino-2-[6-(dimethylamino)purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol
  • Puromycin Aminonucleoside (NSC-3056)
  • C12H18N6O3 PUROMYCIN AMINONUCLEOSIDE
  • 58-60-6 PUROMYCIN AMINONUCLEOSIDE
  • ARDMA
  • 3’-Amino-3’-deoxy-N6,N6-dimethyl?adenosine
  • 3’-amino-3’-deoxy-n,n-dimethyl-adenosine
  • 58-60-6
  • 58-60-4
  • C12H18N6O3
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